Research Studies
Evidence-based insights into GLP-1 receptor agonists and their role in metabolic health. Our commitment to science-backed treatments is reflected in peer-reviewed research.
Efficacy and Safety of Semaglutide in Weight Management
Wilding JPH, et al. • New England Journal of Medicine
A 68-week, double-blind trial involving adults with overweight or obesity showed that weekly subcutaneous semaglutide (2.4 mg) plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.
Tirzepatide Once Weekly for the Treatment of Obesity
Jastreboff AM, et al. • New England Journal of Medicine
In adults with obesity, 2.5 mg, 5 mg, 10 mg, and 15 mg of tirzepatide once weekly provided substantial and sustained reductions in body weight. The safety and side-effect profile of tirzepatide was similar to that of other incretin-based therapies.
Retatrutide: A Novel Triple Agonist for Metabolic Disease
Rosenstock J, et al. • The Lancet
Retatrutide, a single molecule that activates GIP, GLP-1, and glucagon receptors, showed substantial weight loss and improved glycemic control in adults with type 2 diabetes and obesity in a phase 2 trial.
Long-term Cardiovascular Outcomes with Semaglutide
Marso SP, et al. • Circulation
Long-term treatment with semaglutide was associated with a lower risk of cardiovascular events in patients with type 2 diabetes who were at high cardiovascular risk.
Comparative Effectiveness of GLP-1 Receptor Agonists
Blonde L, et al. • JAMA Internal Medicine
A systematic review and network meta-analysis comparing the efficacy and safety of GLP-1 receptor agonists for weight management and glycemic control in adults with obesity.
Metabolic Effects of Triple Hormone Receptor Agonism
Thomas MK, et al. • Nature Medicine
Triple agonists targeting GIP, GLP-1, and glucagon receptors demonstrate superior metabolic benefits compared to dual agonists, with enhanced weight loss and improved insulin sensitivity.
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